Please predict possible top 2 disease causes for this patient case, provide brief explanation, limit to <100 words:

48 year old lady, mother of 2 children, uneducated, right handed, eight months history of forgetfulness involving the household works, failure to recognize the familiar faces and naming them, associated with repeating the words uttered and delayed response to the question asked. She keeps on repeating the same task without interruption. Geographic disorientation and way finding difficulty was present since 1 month. Behavioral symptoms of 2 months duration comprising restlessness, irritable and agitated at times with emotional liability of 1 month duration. She also developed infrequent jerky movements of the trunk and the limbs and tremors of the hands more than legs, bilateral (left side more than right side). Occasional incontinence of urine was present. She was swaying to either side while walking requiring one person support to walk. No preceding history of fever, headache, vomiting and seizures. No history of recent vaccination, dog bite or head injury. She consumes non-vegetarian diet.

She scored 12 over 28 Mini-mental status examination (Folsteine MMSE) scale suggestive of severe dementia. She was suspicious, anxious and fearful with hallucinations. She had insight about her problem but impaired judgement. Significant impairment in recent and immediate memory domains with remote memory being intact. Stimulus sensitive myoclonus was present with auditory startle. No cranial nerve involvement including eye movement abnormalities. She had lower limb rigidity with normal tone in the hands. She had normal power, preserved deep tendon jerks and plantars were flexors. She had postural tremors of both hands, generalised multifocal myoclonic jerks of the trunk and the limbs. Bilateral finger nose in coordination with impaired Tandem gait was present.

Cerebrospinal fluid (CSF) analysis revealed glucose of 72 mg/dl, protein of 20 mg/dl with four lymphocytes. CSF for Gram stain and Acid fast bacillary stain was negative. HSV-DNA PCR was negative in CSF. CSF for 14-3-3 protein was positive 1.5 ng/ml (reference range <1.5 ng/ml). CSF for paraneoplastic panel was negative for anti-Hu, anti-Ma 2 and CV-2.

Magnetic resonance imaging of the brain showed more or less symmetrical T2 and FLAIR hyperintensities of bilateral caudate, putamen, with areas of diffusion restriction (hyperintense on DWI sequence and hypointense on corresponding ADC mapping sequences) in bilateral parietal and occipital gyri (cortical ribboning), insular cortices, cingulate gyri with spared thalami with moderate cortical atrophy. Electroencephalogram revealed periodic sharp waves of diphasic and triphasic morphology without anterior to posterior lag.

Based on the patient's symptoms and test results, I predict the top 2 disease causes as:

1. **Creutzfeldt-Jakob Disease (CJD)**: The patient's rapid progression of dementia, myoclonus, and ataxia, along with the presence of 14-3-3 protein in the CSF, are characteristic of CJD. The MRI findings of symmetrical T2 and FLAIR hyperintensities in the caudate and putamen, as well as cortical ribboning, are also consistent with CJD.
2. **Alzheimer's Disease with Lewy Body Dementia**: The patient's severe dementia, hallucinations, and fluctuating cognitive function are suggestive of Lewy Body Dementia. The presence of postural tremors, rigidity, and myoclonus also supports this diagnosis. While the MRI findings are not typical of Alzheimer's disease, the patient's age and cognitive decline are consistent with this diagnosis.

Note: The patient's symptoms and test results are complex and may require further evaluation to confirm the diagnosis. These predictions are based on the provided information and may not be definitive.

Please predict possible top 2 disease causes for this patient case, provide brief explanation, limit to <100 words:

48 year old lady, mother of 2 children, uneducated, right handed, eight months history of forgetfulness involving the household works, failure to recognize the familiar faces and naming them, associated with repeating the words uttered and delayed response to the question asked. She keeps on repeating the same task without interruption. Geographic disorientation and way finding difficulty was present since 1 month. Behavioral symptoms of 2 months duration comprising restlessness, irritable and agitated at times with emotional liability of 1 month duration. She also developed infrequent jerky movements of the trunk and the limbs and tremors of the hands more than legs, bilateral (left side more than right side). Occasional incontinence of urine was present. She was swaying to either side while walking requiring one person support to walk. No preceding history of fever, headache, vomiting and seizures. No history of recent vaccination, dog bite or head injury. She consumes non-vegetarian diet.

She scored 12 over 28 Mini-mental status examination (Folsteine MMSE) scale suggestive of severe dementia. She was suspicious, anxious and fearful with hallucinations. She had insight about her problem but impaired judgement. Significant impairment in recent and immediate memory domains with remote memory being intact. Stimulus sensitive myoclonus was present with auditory startle. No cranial nerve involvement including eye movement abnormalities. She had lower limb rigidity with normal tone in the hands. She had normal power, preserved deep tendon jerks and plantars were flexors. She had postural tremors of both hands, generalised multifocal myoclonic jerks of the trunk and the limbs. Bilateral finger nose in coordination with impaired Tandem gait was present.

Based on the patient's symptoms and medical history, I predict the top 2 disease causes as:

1. **Creutzfeldt-Jakob Disease (CJD)**: The patient's rapid progression of dementia, myoclonus, and ataxia, along with the presence of stimulus-sensitive myoclonus and auditory startle, are characteristic features of CJD. The absence of fever, headache, and seizures also supports this diagnosis.
2. **Alzheimer's Disease with Lewy Body Dementia**: The patient's severe dementia, hallucinations, and fluctuating cognitive function, along with the presence of rigidity, tremors, and myoclonus, suggest a diagnosis of Lewy Body Dementia. The patient's impaired judgment and insight also support this diagnosis.

Both conditions are neurodegenerative disorders that can cause dementia, motor symptoms, and behavioral changes. Further diagnostic tests, such as imaging studies and laboratory tests, would be necessary to confirm the diagnosis.